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目的研究替吉奥化疗联合同期放疗治疗中晚期食管癌的近期疗效及不良反应。方法 62例不能手术的食管癌患者,随机分为联合放疗组(31例)和单独放疗组(31例),联合放疗组在放疗同时给予替吉奥60 mg/(m2·d)化疗,每6周重复,评价疗效以及不良反应。结果联合放疗组总有效率为87.1%,单独放疗组总有效率为67.7%,差异有统计学意义(P<0.05),不良反应主要表现为骨髓抑制以及放射性食管炎。结论替吉奥化疗同期联合放疗治疗不能手术的食管癌患者,可提高局部控制率,缓解症状,提高生存质量。
Objective To study the short-term curative effect and side effect of treatment of advanced esophageal cancer with tegaserod combined with concurrent radiotherapy. Methods Sixty-two patients with inoperable esophageal cancer were randomly divided into combined radiotherapy group (n = 31) and radiotherapy alone group (n = 31). Radiotherapy combined with radiotherapy 60 mg / (m2 · d) Repeat 6 weeks to evaluate the efficacy and adverse reactions. Results The total effective rate was 87.1% in the combined radiotherapy group and 67.7% in the radiotherapy alone group, the difference was statistically significant (P <0.05). The adverse reactions mainly included myelosuppression and radiation esophagitis. Conclusions The treatment of inoperable esophageal cancer patients with Gio-Chemotherapy and concurrent radiotherapy can improve the local control rate, relieve the symptoms and improve the quality of life.