论文部分内容阅读
目的 观察细胞粘附分子 CD44 v6在口腔鳞癌中的表达 ,了解其与口腔鳞癌组织学分级、肿瘤浸润和转移的关系。 方法 运用免疫组织化学 SP法测定 32例口腔鳞癌和 6例正常口腔粘膜组织中 CD44 v6的表达。 结果 CD44 v6在正常口腔粘膜组织呈强阳性表达 ;癌组织中 CD44 v6的表达明显弱于正常组织 ,但高表达CD44 v6的口腔鳞癌分化较差 ,易发生颈部淋巴结转移。 结论 CD44 v6的表达与口腔鳞癌的浸润、转移有关 ,但能否作为口腔鳞癌诊断和评估预后的标志物有待进一步的研究
Objective To observe the expression of cell adhesion molecule CD44 v6 in oral squamous cell carcinoma and to investigate its relationship with histological grade, tumor invasion and metastasis in oral squamous cell carcinoma. Methods Immunohistochemical SP method was used to detect the expression of CD44 v6 in 32 cases of oral squamous cell carcinoma and 6 cases of normal oral mucosa. Results The positive expression of CD44 v6 was found in normal oral mucosa. The expression of CD44 v6 in cancerous tissues was significantly weaker than that in normal tissues. However, the poorly differentiated oral squamous cell carcinoma with high expression of CD44 v6 and the susceptibility to cervical lymph node metastasis. Conclusions The expression of CD44 v6 is related to the invasion and metastasis of oral squamous cell carcinoma, but whether it can be used as a marker for the diagnosis and prognosis of oral squamous cell carcinoma needs further study