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The three-component reaction of aromatic aldehyde,malononitrile and aliphatic amine in a mixed solvent of methanol and water exhibited very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines,2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used.
The three-component reaction of aromatic aldehyde, malononitrile and aliphatic amine in a mixed solvent of methanol and water showed very interesting molecular diversity and gave the derivatives of polysubstituted N-methyldihydropyridines, 2-dialkylaminopyridines and 2-methoxypyridines as main products according to the structure of aliphatic amines used.