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应用免疫组织化学方法在含有肺鳞癌及其癌前病变的标本上观察了Ｐ５３蛋白和ＰＣＮＡ在肺鳞癌发生过程中出现表达的时间和频率。结果在癌旁正常和鳞状化生的支气管上皮未见ｐ５３蛋白表达，在轻→中→重度不典型增生、原位癌、浸润癌、ｐ５３蛋白表达的阳性率逐渐升高，阳性细胞也逐渐增多。在ｐ５３阳性的不典型增生的支气管上皮，其相应的鳞癌ｐ５３蛋白也呈阳性。ＰＣＮＡ的表达也呈现上述特点，但出现表达的时间早于ｐ５３蛋白。结果表明ｐ５３蛋白和ＰＣＮＡ可作为判断肿瘤发生可能性的有用的标志物，在肺鳞癌的早期诊断中具有重要意义。
The time and frequency of expression of P53 protein and PCNA in the development of squamous cell carcinoma of the lung were observed by immunohistochemistry on specimens containing lung squamous cell carcinoma and precancerous lesions. Results There was no expression of p53 protein in normal and squamous metaplastic bronchial epithelium. The positive rates of mild, moderate, severe dysplasia, carcinoma in situ, invasive carcinoma, and p53 protein expression were gradually increased. increase. In the p53-positive atypical hyperplastic bronchial epithelium, the corresponding squamous cell carcinoma p53 protein is also positive. The expression of PCNA also showed the above characteristics, but the expression appeared earlier than p53 protein. The results show that p53 protein and PCNA can be used as a useful marker to determine the possibility of tumorigenesis, which is of great significance in the early diagnosis of squamous cell carcinoma of the lung.