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源自美国中北部肿瘤治疗组的N0147临床III期试验,研究人员对吸烟与癌症患者结局、无进展生存期(DFS)、出现复发的时间间隔(TTR)的关系进行评价,结果发现,与不吸烟人群相比,经常吸烟患者的DFS明显较短,对于BRAF基因野生型结肠癌患者,吸烟与患者较短的DFS有关,而BRAF基因突变型患者则无此关联。研究人员最后认为,对于结肠癌患者整体而
The N0147 Phase III trial, derived from the North-Central American Oncology Group, evaluated the relationship between smoking and cancer patient outcome, progression-free survival (DFS), and time to recurrence (TTR) Compared with smokers, patients with frequent smokers had significantly shorter DFS, and smoking was associated with shorter DFS in patients with BRAF-expressing wild-type colon cancer, whereas patients with BRAF-mutated patients had no association. The researchers concluded that the overall colon cancer patients