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目的探讨肝炎后肝硬化患者部分血清酶学、脂蛋白及蛋白质等指标变化与死因预后的关系。方法观察1998年～2003年在大同市第四人民医院住院的65例肝炎后肝硬化死亡患者和同期住院的85例肝炎后肝硬化生存患者的部分酶学、蛋白质及蛋白指标。结果反映肝细胞坏死的指标死亡组和生存组间无显著差异。而血清CHE、白蛋白、HDL-C、ApoA1等反映肝细胞合成功能的指标的下降两组有显著差异。结论反映肝细胞合成功能的指标血清CHE、白蛋白HDL-C、ApoA1的下降幅度可以作为判断肝炎后肝硬化预后较敏感的指标。
Objective To investigate the relationship between the changes of some serum enzymes, lipoprotein, protein and prognosis in patients with posthepatitic cirrhosis. Methods A total of 65 patients with posthepatitic cirrhosis who were hospitalized in the Fourth People ’s Hospital of Datong City from 1998 to 2003 were enrolled in this study. The enzyme, protein and protein indexes of 85 patients with posthepatitic cirrhosis who were hospitalized in the same period were observed. The results reflect the indicators of hepatocyte necrosis between the death group and the survival group no significant difference. The serum CHE, albumin, HDL-C, ApoA1 and other indicators reflect the decline of hepatocyte synthesis decreased significantly between the two groups. Conclusion The decrease of serum CHE, albumin HDL-C and ApoA1, which can reflect the function of hepatocyte synthesis, can be used as an index to judge the prognosis of posthepatitic cirrhosis.