论文部分内容阅读
对分离自南海海绵的真菌Penicillium terrestre中的化学成分进行研究。采用多种色谱手段进行分离纯化,得到单体化合物,通过理化性质及波谱方法(1D,2D NMR)确定化合物结构。分离得到的8个化合物分别为cyclo(glycyl-D-proline)(1),cyclo(L-prolyl-L-alanine)(2),cyclo(L-prolyl-D-alanine)(3),cyclo(L-leucyl-trans-4-hydroxy-L-proline)(4),cyclo(L-leucyl-cis-4-hydroxy-D-proline)(5),cyclo(L-trans-(4-hydroxyprolinyl)-L-phenylalanine)(6),hexylitaconic acid(7),hexylitaconicmethylate(8)。化合物7,8为首次从该属中分得,其余化合物为首次从该种中分得。
The chemical composition of the fungus Penicillium terrestre isolated from the South China Sea sponge was studied. A variety of chromatographic methods were used to separate and purify the compounds to obtain the monomer compounds. The structures of the compounds were determined by physico-chemical properties and spectroscopic methods (1D, 2D NMR). The eight compounds isolated were cyclo (glycyl-D-proline) (1), cyclo (L-prolyl-L-alanine) L-leucyl-trans-4-hydroxy-L-proline (4), cyclo (L-leucyl-cis- L-phenylalanine (6), hexylitaconic acid (7), hexylitaconic methylate (8). Compounds 7 and 8 were isolated from this genus for the first time, and the remaining compounds were isolated from this species for the first time.