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目的通过分析慢性乙型肝炎病毒(HBV)感染与代谢综合征(MS)之间的相关性,探讨慢性HBV感染是否为心血管疾病发生潜在的危险因素之一。方法采用横断面的分析方法 ,纳入2013年1月1日至2014年3月31日在新疆克拉玛依市中心医院参加体检的成年人,自制表格记录参与者一般资料及相关血清学指标,将确诊为慢性HBV感染患者分为男性组和女性组,通过Logistic回归分别探讨慢性HBV感染与MS及其组成部分的相关性。结果共4 437例参与者入组,其中确诊为慢性HBV感染患者为324例(7.3%),MS患者为115例(2.6%);在男性组,慢性HBV感染与高甘油三酯血症及MS呈负相关关系(P<0.05);在女性组,慢性HBV感染与高甘油三酯血症呈负相关关系(P<0.05),但与代谢综合征无显著相关性(P>0.05)。结论慢性HBV感染与男性高甘油三酯血症、MS及女性高甘油三酯血症呈明显负相关关系。
Objective To investigate whether chronic HBV infection is one of the potential risk factors of cardiovascular disease by analyzing the correlation between chronic hepatitis B virus (HBV) infection and metabolic syndrome (MS). Methods A cross-sectional analysis method was used to include adults participating in the physical examination at Karamay Central Hospital in Xinjiang from January 1, 2013 to March 31, 2014. Self-made tables were used to record the general information of the participants and related serological indicators. Patients with chronic HBV infection were divided into male and female groups. Logistic regression was used to investigate the relationship between chronic HBV infection and MS and its components. Results A total of 4 437 participants were enrolled, of whom 324 (7.3%) were diagnosed as having chronic HBV infection and 115 (2.6%) with MS. In the men with chronic HBV infection and hypertriglyceridemia and (P <0.05). In the female group, there was a negative correlation between chronic HBV infection and hypertriglyceridemia (P <0.05), but no significant correlation with metabolic syndrome (P> 0.05). Conclusion Chronic HBV infection has a negative correlation with hypertriglyceridemia, MS and female hypertriglyceridemia.