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依托咪酯“批号工03”经动物实验证实:(1)猕猴中全麻持续时间8±3min和苏醒时间20±5min。(2)家兔分别给以0.25mg/kg或1.50mg/kg,前者ECG、HR和MAP(动脉均压)无明显变化,后者HR显著减慢(p<0.01)和MAP明显升高,且ECG示P-R间期延长和P波平坦。(3)小鼠按双盲法与“批号标C1”作对照,LD_(50)/ED_(50)无显著差别。 依托咪酯“批号工03”经临床应用368例证实了:(1)作用启效时间45±15s、作用持续时间9±3min和清醒3±1min。(2)为了避免气管插管可引起MAP升高和HR增快,诱导剂量以400-500μg/kg为宜。(3)静注顺序分芬太尼2μg/kg-依托咪酯-琥珀胆碱2mg/kg或潘库溴铵100±20μg/kg芬太尼-依托咪酯,后者更可取。(4)能促使血糖升高,对琥珀胆碱所导致高钾血症无助。(5)与既知的静脉全麻药比较,对血流动力学的影响最轻微。
Etomidate “Batch No. 03” confirmed by animal experiments: (1) The duration of general anesthesia in macaques 8 ± 3min and wake up time 20 ± 5min. (2) Rabbits were given 0.25mg / kg or 1.50mg / kg respectively. There was no significant change of ECG, HR and MAP in the former rabbits, but HR in the latter was significantly decreased (p <0.01) The ECG showed PR interval prolongation and P wave flat. (3) There was no significant difference between LD 50 / ED 50 in double-blind mice and control of lot number C1. Etomidate Lot No. 03 was confirmed by clinical application of 368 cases: (1) The onset of action was 45 ± 15 seconds, the duration of action was 9 ± 3 minutes and the awakeness was 3 ± 1 minutes. (2) In order to avoid tracheal intubation can cause elevated MAP and HR, induced dose to 400-500μg / kg is appropriate. (3) intravenous fentanyl 2μg / kg-etomidate-succinylcholine 2mg / kg or panquromide 100 ± 20μg / kg fentanyl-etomidate, the latter is more preferable. (4) can promote blood sugar, help hyperkalemia caused by succinylcholine helpless. (5) Hemodynamics has the slightest effect compared to known intravenous anesthetics.