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目的分析2012年济南市手足口病的病原学及流行特征。方法采用实时荧光定量PCR方法(real-time PCR),同时检测肠道病毒71型(HEV71)、柯萨奇病毒A组16型(CVA16)及肠道病毒其他型(PE)。结果 2012年济南市各医院所送手足口病样本859例(包括重症46例),阳性662例,总阳性率为77.1%;其中HEV71占22.1%(190/859),CVA16占41.9%(360/859),HEV71和CVA16混合感染占0.9%(8/859),非HEV71和CVA16的肠道病毒其他型(PE)占12.1%(104/859)。病例多发生于6岁以下儿童,普通病例中以CVA16感染为主;重症多发生于3岁以下儿童,以HEV71感染为主。结论 2012年济南市手足口病病原以CVA16为主,并存在HEV71和CVA16混合感染;重症病例以HEV71为主,多发生于3岁以下儿童。
Objective To analyze the etiology and epidemiology of HFMD in Jinan in 2012. Methods Real-time PCR was used to detect enterovirus 71 (HEV71), Coxsackievirus A (CVA16) and other types of enterovirus (PE). Results A total of 859 cases of hand-foot-mouth disease (including 46 severe cases) were sent out from hospitals in Jinan City in 2012. The positive rate was 77.1%, with a positive rate of 77.1%. Among them, HEV71 accounted for 22.1% (190/859) and CVA16 41.9% / 859), mixed infections of HEV71 and CVA16 accounted for 0.9% (8/859), and non-HEV71 and CVA16 accounted for 12.1% (104/859) for other types of enterovirus (PE). Case occurred in children under 6 years of age, the common case of CVA16 infection; severe cases occurred in children under 3 years old, with HEV71 infection. Conclusions In 2012, the pathogen of HFMD in Jinan was mainly CVA16, and there was a mixed infection of HEV71 and CVA16. The severe cases were mainly HEV71 and occurred mostly in children under 3 years of age.