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目的:探讨P~(16)基因低表达在喉癌的发生发展及患者生存时间的关系。方法:采用免疫组化方法对49例喉癌与癌旁组织,26例喉部良性病变组织中P~(16)蛋白进行检测。结果:发现①49例喉癌中P~(16)蛋白表达阳性率为47.9％(23/49),癌旁组织中P~(16)蛋白表达阳性率为68.7％,26例喉良性病变中P~(16)蛋白表达阳性率为100％,三者之间的检出率存在显著性差异(P<0.01);②23例P~(16)蛋白表达阳性的患者中5例死于术后半年,10例死于术后1年,8例死于术后1年半;26例P~(16)蛋白表达阴性的患者中,15例死于术后半年,其中3例癌旁组织中P~(16)蛋白表达阳性;6例死于术后1年,其中1例癌旁组织中P~(16)蛋白表达阳性;2例死于术后1年半,癌旁组织中P~(16)蛋白皆表达阴性;P~(16)蛋白表达阳性的患者与阴性的患者之间,死亡率存在显著性差异(P<0.01)。结论:①P~(16)基因低表达与喉癌发生发展有关;②P~(16)蛋白的阴性表达可能与患者的生存时间有关。
Objective: To investigate the relationship between the low expression of P ~ (16) gene and the development of laryngeal cancer and the survival time of patients. Methods: Immunohistochemistry was used to detect the expression of P ~ (16) protein in 49 cases of laryngeal carcinoma and adjacent non - cancerous tissues and 26 cases of benign lesions of the larynx. Results: ① The positive rate of P ~ (16) protein in 47 cases of laryngeal carcinoma was 47.9% (23/49), the positive rate of P ~ (16) protein was 68.7% in 26 cases of laryngeal benign lesions The positive rate of ~ (16) protein expression was 100%, there was a significant difference between the three detection rates (P <0.01). ② Of the 23 patients with positive expression of P ~ (16) protein, 5 patients died after six months , 10 died 1 year after operation and 8 died 1 year and a half after operation. Of the 26 patients with negative expression of P ~ (16) protein, 15 patients died six months after operation, of which 3 cases had P (16) protein was positive in 6 cases, one case died of one year after operation, and the expression of P 16 protein in one case of paracancerous tissue was positive. 16) protein expression was negative; there was significant difference (P <0.01) in mortality between patients with positive P ~ (16) protein expression and negative patients. Conclusion: ① The low expression of P ~ (16) gene is related to the occurrence and development of laryngeal carcinoma; ② The negative expression of P ~ (16) may be related to the survival time of patients.