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目的 探讨系统性红斑狼疮(SLE)患者及梅毒患者血清抗心磷脂抗体(ACA)、抗β2糖蛋白I(β2GPI)抗体水平及其相互关系。方法 随机采集35例SLE活动期患者血液标本及70例梅毒患者血液标本,采用EUSA法测定血清中ACA及抗β2GPI抗体水平。结果 SLE患者ACA及抗β2GPI抗体水平均明显升高,ACA阳性率为57.1％(20/35),抗β2GPI抗体阳性率为94.3％(33/35)。梅毒患者ACA水平明显升高,抗β2GPI抗体水平无明显变化,ACA阳性率为88.6％(62/70),抗β2GPI抗体阳性率为4.3％(3/70)。结论 抗β2GPI抗体有助于区分自身免疫型ACA和非自身免疫型ACA,可能成为SLE诊断及研究分析的重要实验室指标。
Objective To investigate the serum anti-cardiolipin antibody (ACA) and anti-β2 glycoprotein I (β2GPI) antibody levels in patients with systemic lupus erythematosus (SLE) and syphilis. Methods Blood samples from 35 SLE patients and 70 syphilis patients were collected randomly. The levels of serum ACA and anti-β2GPI antibodies were measured by EUSA. Results The levels of ACA and anti-β2GPI antibodies were significantly increased in SLE patients. The positive rate of ACA was 57.1% (20/35) and the positive rate of anti-β2GPI antibody was 94.3% (33/35). The level of ACA in patients with syphilis was significantly higher than that in patients without syphilis. The positive rate of ACA was 88.6% (62/70) and that of anti-β2GPI was 4.3% (3/70). Conclusion Anti-β2GPI antibody can help differentiate autoimmune ACA from non-autoimmune ACA and may be an important laboratory index for SLE diagnosis and research analysis.