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目的了解冻干水痘减毒活疫苗接种后的反应和免疫效果,为进行大规模水痘疫苗接种提供依据。方法在辖区内随机选择125名1周岁以上的儿童,接种冻干水痘减毒活疫苗。结果125名儿童均未发现不良反应;血清抗体阳转率为92.86%,GMT为12.93。免疫前后抗体水平差异有非常显著意义(t=5.87,P>0.001)。结论冻干水痘减毒活疫苗接种后临床反应轻微,免疫效果理想。
Objective To understand the response and immunological effects of vaccinated live attenuated varicella vaccine and provide the basis for large-scale chickenpox vaccination. Methods A total of 125 children over the age of 1 years were randomly selected in the area and inoculated with live attenuated vaccine of freeze-dried chickenpox. Results No adverse reactions were found in 125 children. The positive rate of serum antibody was 92.86% and the GMT was 12.93. The difference of antibody level before and after immunization was very significant (t = 5.87, P> 0.001). Conclusions The live attenuated vaccine of freeze-dried varicella vaccine has mild clinical response after vaccination, and the immune effect is satisfactory.