论文部分内容阅读
目的采用回顾性病例对照研究的方法,调查、收集和分析安徽地区肝内胆管结石患者的生活资料,分析可能导致该病的危险因素。方法病例组和对照组样本均选自安徽医科大学第一附属医院2012年1月—2013年6月的住院病例。病例组样本均为经手术证实的肝内胆管结石患者,对照组采用1∶1配对方法,选择经腹部影像学检查排除胆道系统结石的患者。数据收集采用统一的流行病学问卷调查表,收集2组样本的一般情况、生活环境和体格检查等资料,并录入SPSS 13.0软件中。首先对各变量进行单因素Logistic回归分析,然后对可能受到混杂因素干扰的变量进行多因素Logistic回归分析,最后将筛选出的因素拟合主效应模型并分别计算人群特异危险度百分比(PAR%)。结果肝内胆管结石的危险因素包括低身高体重指数(P<0.001,OR=17.295,PAR%64.19%)、低油脂饮食(P<0.001,OR=7.583,PAR%54.23%)、井水水源(P=0.008,OR=7.806,PAR%55.06%)、胆道蛔虫病史(P=0.001,OR=7.537,PAR%24.63%)和胆道炎症史(P<0.001,OR=12.491,PAR%25.64%)。结论安徽地区肝内胆管结石的危险因素包括低身高体重指数、低油脂摄入、井水水源、胆道蛔虫病史和胆道炎症史。
Objective To investigate retrospective case-control study to collect and analyze living materials in patients with intrahepatic bile duct stones in Anhui province and analyze the risk factors that may lead to the disease. Methods The cases and control samples were selected from the first affiliated hospital of Anhui Medical University from January 2012 to June 2013 inpatient cases. The patients in the case group were surgically confirmed patients with intrahepatic bile duct stones, the control group using 1: 1 matching method, choose the abdominal imaging examination to exclude patients with biliary stone. Data collection The unified epidemiological questionnaire was used to collect the general information of two groups of samples, living environment and physical examination data, and input into SPSS 13.0 software. Logistic regression analysis was carried out on all the variables first, and then multivariate logistic regression analysis was conducted on the variables that may be disturbed by the confounding factors. Finally, the selected factors were fitted to the main effect model and the percentage of specific population-specific risk (PAR%) was calculated. . Results The risk factors of intrahepatic bile duct stones included low body mass index (P <0.001, OR = 17.295, PAR% 64.19%), low fat diet (P <0.001, OR = 7.583, PAR% P = 0.008, OR = 7.806, PAR% 55.06%), history of biliary ascariasis (P = 0.001, OR = 7.537, PAR% 24.63%) and history of biliary inflammation (P <0.001, OR = 12.491, PAR% 25.64%). Conclusions The risk factors of intrahepatic bile duct calculi in Anhui Province include low body mass index, low fat intake, well water, history of biliary ascariasis and biliary inflammation.