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β-葡萄糖醛酸酶在多种癌症和其它疾病中增高。关于胃癌组织胃液中这种酶活力的增高也有许多报道。但是由于胃癌同其它胃病病人的胃液β-葡萄糖醛酸酶活力有相当一部分交叉重叠,不易作出鉴别诊断。Piper等人曾报道这种酶是区别胃部良性病变或恶化的一个可靠指针。这种酶在pH3.8以下不稳定,pH5.5以上活力迅速下降,其最适pH为4.0～5.5。因此,胃液偏硷或pH低于4.0,这种酶的活力都不呈现增高。
Beta-glucuronidase is elevated in many cancers and other diseases. There are also many reports on the increase of this enzyme activity in gastric juice of gastric cancer. However, due to gastric cancer with other gastric diseases in patients with gastric juice β-glucuronidase activity a considerable part of the overlap, difficult to make a differential diagnosis. Piper et al. Reported that this enzyme is a reliable indicator of benign or malignant gastric lesions. The enzyme is unstable below pH3.8, its activity rapidly drops below pH5.5, and its optimum pH is 4.0-5.5. Therefore, gastric alkaline or pH below 4.0, the enzyme showed no increase in activity.