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目的通过3例慢性阻塞性肺疾病急性加重期(AECOPD)患者应用头孢吡肟后出现精神症状的临床分析,观察头孢吡肟引起的精神改变等不良反应,对临床抗菌药物应用的起到指导作用。方法通过3例疑似药物引起精神症状的用药分析,要求加强抗菌药物的监测。结果这3例药物不良反应(ADR)是不合理用药引起的。结论加强第4代头孢菌素抗生素的管理,合理应用具有重要的意义。
Objective To investigate the clinical effects of cefepime in 3 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and to observe the adverse reactions of cefepime-induced changes in psychology and to guide the clinical use of antimicrobial agents . Methods Three cases of suspected drug-induced psychiatric symptoms of drug analysis, requiring the strengthening of antimicrobial drug monitoring. Results of these three cases of adverse drug reactions (ADR) is caused by irrational use of drugs. Conclusion It is of great importance to strengthen the management of the 4th generation cephalosporin antibiotics and make rational use of them.