【摘 要】
：
目的制备治疗白癜风的补骨脂素脂质体凝胶,对其体外释药模式进行定量考察.方法以同浓度的补骨脂素凝胶为对照,用透析法检测补骨脂素脂质体凝胶的体外释药模式,并对其在4 ℃下
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目的制备治疗白癜风的补骨脂素脂质体凝胶,对其体外释药模式进行定量考察.方法以同浓度的补骨脂素凝胶为对照,用透析法检测补骨脂素脂质体凝胶的体外释药模式,并对其在4 ℃下贮存3周的释药稳定性进行研究.结果与补骨脂素凝胶比较,补骨脂素脂质体凝胶具有明显的缓释及长效作用,且前3 h释药符合Higuchi扩散模式(k=4.67%h-1/2),3 h后遵循零级释药模式(k=0.74%h-1).而补骨脂素凝胶在实验的24 h内释药均符合Higuchi扩散模式(k=7.18%h-1/2).在贮存期内,补骨脂素脂质体凝胶的
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