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目的 临床指南需要根据相关研究结果定期审查以确保其可靠性,但在更新临床指南的过程中仍然缺乏对于更新过程表述的优先报告条目.本文旨在介绍更新版指南报告清单(Checklist for the Reporting of Updated Guidelines,CheckUp)及其制定过程.方法 基于临床指南更新的研究证据的概述,指南研究与评价工具(Appraisal of Guidelines for Research and Evaluation Ⅱ,AGREE Ⅱ)和报告清单专家组(33位)的建议开发了初始清单的各条目.然后,使用多个步骤对本清单进行了完善,包括评估10个现有的更新版临床指南,对关键信息提供者进行访谈[应答率为54.2％ (13/24)],清单制定专家组内部进行的一个三轮的德尔菲(Delphi)共识调查,以及来自于临床指南方法学专家[应答率为90％ (53/59)]和指南使用者[应答率为55.6％ (10/18)]的外部评审意见.结果 清单最终包括16个条目,主要涉及:(1)更新版指南的呈现;(2)编辑独立性;(3)更新过程采用的方法.结论 更新版指南的报告清单作为一个工具可用于评估更新版指南报告的完整性,并为指南制定者提供撰写报告的要求.“,”Background Scientific knowledge is in constant development.Consequently,regular review to assure the trustworthiness of clinical guidelines is required.However,there is still a lack of preferred reporting items of the updating process in updated clinical guidelines.The present article describes the development process of the Checklist for the Reporting of Updated Guidelines (CheckUp).Methods and Findings We developed an initial list of items based on an overview of research evidence on clinical guideline updating,the Appraisal of Guidelines for Research and Evaluation (AGREE) Ⅱ Instrument,and the advice of the CheckUp panel (n =33 professionals).A multistep process was used to refine this list,including an assessment of ten existing updated clinical guidelines,interviews with key informants (response rate:54.2％;13/24),a three-round Delphi consensus survey with the CheckUp panel (33 participants),and an external review with clinical guideline methodologists (response rate:90％;53/59) and users (response rate:55.6％;10/18).CheckUp includes 16 items that address (1) the presentation of an updated guideline,(2) editorial independence,and (3) the methodology of the updating process.In this article,we present the methodology to develop CheckUp and include as a supplementary file an explanation and elaboration document.Conclusions CheckUp can be used to evaluate the completeness of reporting in updated guidelines and as a tool to inform guideline developers about reporting requirements.Editors may request its completion from guideline authors when submitting updated guidelines for publication.Adherence to CheckUp will likely enhance the comprehensiveness and transparency of clinical guideline updating for the benefit of patients and the public,health care professionals,and other relevant stakeholders.