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目的:了解去甲万古霉素的不良反应和肾功能不全患者的给药方案,以指导临床用药。方法:检索在中国知网发表的关于去甲万古霉素不良反应专题观察、临床疗效评价中涉及不良反应报道的文献进行循证评价;检索关于肾功能不全患者应用去甲万古霉素制订给药方案的文献以了解确定给药剂量方法。结果:去甲万古霉素不良反应发生率约为9.3%,由高到低依次为肾功能损害、肝功能异常、皮肤反应、消化道反应、耳毒性、静脉炎、血象异常、头晕头痛、药物热,老年人及合并使用肾损害药物者的发生率较高;肾功能不全患者能根据肾功能损害程度确定给药剂量。结论:去甲万古霉素在临床用药中要避免合并使用肾损害药物,使用中除监测耳肾毒性外,还应监测肝功能,尤其是老年人;肾功能不全患者根据肾功能损害程度确定给药剂量的方法适用于临床使用。
Objective: To understand the adverse reactions of norvancomycin and renal dysfunction in patients with drug delivery programs to guide clinical medication. METHODS: The articles published in CNKI on the observation of adverse reactions of norvancomycin and evidence of adverse reactions in the evaluation of clinical efficacy were searched. Evidence-based evaluation was performed on patients with renal insufficiency who were prescribed vancomycin Protocol literature to determine the method of dosing. Results: The incidence of adverse reactions of norvancomycin was about 9.3%, followed by renal dysfunction, abnormal liver function, skin reaction, digestive tract reaction, ototoxicity, phlebitis, abnormal blood flow, dizziness and headache, and drug Fever, the elderly and the combined use of renal damage drugs were higher incidence of patients with renal insufficiency can be based on the degree of renal impairment to determine the dose. Conclusion: Norvancomycin should be avoided in the clinical use of drugs combined with renal damage, in addition to monitoring ototoxicity, but also monitoring of liver function, especially the elderly; patients with renal insufficiency based on the degree of renal impairment to determine The method of dosage is suitable for clinical use.