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目的:探究不同血液净化方式对尿毒症维持性血液透析患者甲状旁腺素的影响。方法:选取2013年7月至2015年8月收治入珠海市中西医结合医院治疗的尿毒症维持性血液透析患者102例,按照随机双盲法分成3组,即低通量血液透析组(单纯组1)、高通量血液透析组(单纯组2)以及血液透析联合血液灌流组(联合组),各34例,对比各组治疗效果,观察不同血液净化方式对患者甲状旁腺素的影响。结果:入院时3组患者甲状旁腺素水平比较,差异无统计学意义(P>0.05),经过各自治疗后,甲状旁腺素水平均改善,单纯组2与联合组比较,差异无统计学意义(P>0.05),与单纯组1比较,差异具有统计学意义(P<0.05),单纯组2和联合组的甲状旁腺素清除率均优于单纯组1,差异具有统计学意义(P<0.05)。结论:尿毒症维持性血液透析患者的临床治疗,应根据患者具体情况选择合适的血液透析方法,其中高通量血液透析以及血液透析联合血液灌流的方式对患者甲状旁腺素的改善效果较为显著。
Objective: To investigate the effect of different blood purification methods on parathyroid hormone in maintenance hemodialysis patients with uremia. Methods: A total of 102 patients with uremic maintenance hemodialysis admitted to Zhuhai Integrative Medicine Hospital from July 2013 to August 2015 were randomly divided into three groups according to a randomized double-blind method: low-flux hemodialysis group Group 1), high-throughput hemodialysis group (group 2) and hemodialysis combined hemoperfusion group (combination group), 34 cases in each group. The effects of different blood purification methods on parathyroid hormone were observed . Results: There was no significant difference in parathyroid hormone levels between the three groups on admission (P> 0.05). After treatment, the levels of parathyroid hormone were all improved. There was no significant difference between group 2 and the combined group (P <0.05). Compared with the simple group 1, the difference was statistically significant (P <0.05), the parathyroid hormone clearance rate in the simple group 2 and the combined group was better than that in the simple group 1, the difference was statistically significant P <0.05). Conclusion: The clinical treatment of uremic patients with maintenance hemodialysis should be based on the specific circumstances of patients choose the appropriate hemodialysis method, including high-throughput hemodialysis and hemodialysis combined with hemoperfusion way to improve the effect of parathyroid hormone in patients was more significant .