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迄今,大量的动物实验和流行病学调查资料,并没有为苯乙烯的致癌作用提供确切的证据。虽然长期经口致癌实验表明,高剂量组啮齿类动物的前胃鳞状上皮细胞癌明显增加,但毒物代谢动力学和大分子结合研究的最新成果表明,苯乙烯及其7,8-氧化物不可能是动物和人类的致癌剂。7,8-氧化物致啮齿类动物前胃癌应是局部大剂量长期刺激的结果。
To date, a large number of animal experiments and epidemiological investigations have not provided definitive evidence for the carcinogenic effects of styrene. Although long-term oral carcinogenicity experiments showed that the rodent squamous cell carcinoma of the high-dose group significantly increased in squamous cell carcinoma of the antrum, the latest results from studies on toxicokinetics and macromolecular binding showed that styrene and its 7,8-oxide Impossible to be animal and human carcinogen. 7,8-Oxide-induced rodent anterior gastric cancer should be the result of long-term local, high-dose stimulation.