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例1,男,46岁,乙肝病毒携带10余年,近4～5年,肝功异常,口服拉米夫定1年余后停药,1个月后出现极度乏力,消化道症状明显,黄疸进行性上升,PTA24%,确诊为慢重肝后,本人要求转入外地治疗,未继续随访。例2,男,45岁,乙肝确诊4～5年,曾以慢乙肝反复住院2次,均好转出院,未用其他抗病毒治疗,本次应用拉米夫定15个月,用药期间几次复查肝功均正常,但一直未出现HBeAg转换,HBVDNA持续阳性,停药1个半月左右,患者出现乏力感加重,消化道症状明显,黄疸进行性的上升,PTA:43%,YMDD(+),疑似重症肝炎,后加强支持疗法,人工肝支持系统治疗,对症治疗,2个月后好转出院。例3,男,42岁,乙肝病毒携带10余年,ALT反复波动于
Case 1, male, 46 years old, hepatitis B virus carrying more than 10 years, nearly 4 to 5 years, abnormal liver function, oral lamivudine after more than 1 year withdrawal, 1 month after the emergence of extreme fatigue, gastrointestinal symptoms, jaundice Progressive increase, PTA24%, diagnosed as chronic severe liver, I asked to transfer to field treatment, did not continue follow-up. Example 2, male, 45 years old, hepatitis B diagnosed 4 to 5 years, once repeatedly hospitalized with chronic hepatitis B twice, were better discharged, no other antiviral therapy, the application of lamivudine 15 months, several times during the medication The liver function tests were normal, but no HBeAg conversion was observed. The positive rate of HBVDNA continued to be positive. After stopping for about one and a half months, the patients experienced aggravated symptoms of aggravating gastrointestinal symptoms and jaundice. PTA was 43% and YMDD (+ , Suspected severe hepatitis, after strengthening supportive therapy, artificial liver support system therapy, symptomatic treatment, 2 months after the discharge improved. Example 3, male, 42 years old, hepatitis B virus more than 10 years, ALT repeatedly fluctuated in