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目的:检测水通道蛋白9(Aquaporin 9,AQP9)mRNA在子痫前期患者胎盘中的表达,以探讨AQP9在子痫前期发病机制中的意义。方法:用半定量逆转录聚合酶链反应(RT-PCR)技术检测正常妊娠(10例)、子痫前期(22例)剖宫产后胎盘中AQP9基因在转录水平的表达。结果:子痫前期组胎盘中AQP9 mRNA表达量较正常妊娠组显著升高(P<0.01)。结论:AQP9在子痫前期的发病中起着重要作用,可能与AQP9表达增加有关。
Objective: To detect the expression of aquaporin 9 (AQP9) mRNA in the placenta of preeclampsia patients and to explore the significance of AQP9 in the pathogenesis of preeclampsia. Methods: The expression of AQP9 gene in placenta of normal pregnancy (10 cases) and preeclampsia (22 cases) after cesarean section was detected by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) Results: The expression of AQP9 mRNA in placenta of preeclampsia group was significantly higher than that of the normal pregnancy group (P <0.01). Conclusion: AQP9 plays an important role in the pathogenesis of preeclampsia and may be related to the increase of AQP9 expression.