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采用免疫组化SP法检测216例大肠癌组织中p27kipl和基质金属蛋白酶(MMP)-9的表达。p27kipl阳性表达166例(76.9%),低表达141例(65.3%),瘤细胞核、质共表达73例(33.8%);MMP-9阳性表达183例(84.7%),高表达98例(45.4%)。p27kipl、MMP-9表达与大肠癌分化程度、Dukes分期、患者生存期、淋巴结转移及器官转移密切相关(P均<0.05)。认为p27kipl低表达和MMP-9高表达在大肠癌的进展中发挥重要作用,二者可作为判断大肠癌侵袭、转移及预后的生物学指标。
Immunohistochemical SP method was used to detect the expression of p27kipl and matrix metalloproteinase (MMP)-9 in 216 colorectal cancer tissues. P27kipl was positively expressed in 166 cases (76.9%), low expression in 141 cases (65.3%), neoplastic and nuclear expression in 73 cases (33.8%); MMP-9 positive expression in 183 cases (84.7%), high expression in 98 cases (45.4) %). The expressions of p27kipl and MMP-9 were closely related to the degree of differentiation of colorectal carcinoma, Dukes stage, survival time, lymph node metastasis and organ metastasis (P < 0.05). It is believed that low expression of p27kipl and high expression of MMP-9 play an important role in the progression of colorectal cancer, and both of them can be used as biological indicators to judge the invasion, metastasis and prognosis of colorectal cancer.