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以随机双盲法将110例高血压病患者分为倍他乐克缓释片组(56例)及平片组(54例),观察其疗效和不良反应。结果二组的降压疗效相似。双盲期始末对比,两组降压值均有非常显著意义(P<0.001),但两组间期末降压值对比则无显著性差异。卧位降压疗效,两组均为66.1％,立位则分别为68.5％及59.2％。在缓解症状方面(尤以头痛、头昏)缓释片组效果较好,较长期应用,副作用少且轻,未见明显的代谢异常,对肾功亦无不良影响。
110 patients with hypertension were divided into metoprolol sustained-release tablets group (56 cases) and plain tablets group (54 cases) by randomized double-blind method. The curative effect and adverse reactions were observed. The results of two groups of antihypertensive efficacy similar. Double blind period comparison, the two groups of antihypertensive values were very significant (P <0.001), but the end of the two groups between the end of the antihypertensive value was no significant difference. The antihypertensive effect was 66.1% in both groups and 68.5% and 59.2% in standing position respectively. In relieving symptoms (especially headache, dizziness) sustained-release tablets group is better, longer-term use, less side effects and light, no significant metabolic abnormalities, no adverse effects on kidney function.