黄连素(Berberin)是一种季铵化合物,长期以来一直作为抗生素应用于临床。八十年代初,国外动物实验研究表明,它可以防治实验性心律失常。1985年黄伟民等首先报道黄连素治疗人类室性快速心律失常取得较满意疗效。随后的一些动物和临床研究也进一步证实黄连素的确具有抗心律失常的作用,并有较好的临床效果。 1药代动力学黄连素口服仅缓慢吸收少量,血浓度一般在0.1mg/dl左右,吸收入血后迅速进入体内几乎所有组织。它在各组织中贮留的时间甚为短暂,主要通过肝脏代谢,其代谢产物由肾脏排泄。 2血液动力学效应动物实验结果表明,小剂量黄连素(1～5mg/kg)具有正性肌力作用,而大剂量(10～30mg/kg)则抑制心肌,减弱其收缩力。黄连素以负性频率为主;扩张外周血管,也能扩张 Berberin is a quaternary ammonium compound that has long been used as an antibiotic in the clinic. The early 1980s, foreign animal experiments show that it can prevent experimental arrhythmia. In 1985, Huang Weimin et al first reported that berberine treatment of ventricular tachyarrhythmia obtained more satisfactory results. Subsequent animal and clinical studies have further confirmed that berberine indeed anti-arrhythmic effect, and have a good clinical effect. 1 pharmacokinetics berberine slowly absorbed only a small amount of oral, blood concentration is generally about 0.1mg / dl, absorbed into the blood quickly into the body almost all the tissues. It holds very short periods of time in the tissues, mainly through the liver, whose metabolites are excreted by the kidneys. 2 Hemodynamic effects Animal experiments showed that low doses of berberine (1 ~ 5mg / kg) positive inotropic effect, and high doses (10 ~ 30mg / kg) inhibition of myocardial and reduce their contractility. Berberine mainly negative frequency; expansion of peripheral vessels, but also expansion