论文部分内容阅读
目的探讨血清胱抑素C(Cys-C)水平测定对代谢综合征患者早期肾功能损害的临床诊断价值。方法收集42例高血压、48例2型糖尿病及98例代谢综合征患者的血清标本。用酶法测定血清肌酐、尿素氮,用颗粒增强免疫比浊法测定血清Cys-C。结果原发性高血压、2型糖尿病及代谢综合症患者中血清Cys-C的异常检出率(52.38%、39.58%、58.16%)明显高于血清肌酐(16.67%、25.00%、45.92%)、尿素氮(11.90%、22.92%、36.73%);高血压、糖尿病、代谢综合征患者血清Cys-C水平均较正常对照组明显升高,差异有统计学意义(P均<0.05),而BUN水平与对照组无显著差异(P>0.05),代谢综合征组SCr水平明显高于对照组(P<0.05)。结论血清Cys-C可作为代谢综合征早期肾功能损害的辅助诊断指标之一。
Objective To investigate the value of serum cystatin C (Cys-C) in the diagnosis of early renal dysfunction in patients with metabolic syndrome. Methods Serum samples from 42 patients with hypertension, 48 patients with type 2 diabetes mellitus and 98 patients with metabolic syndrome were collected. Serum creatinine and urea nitrogen were measured by enzymatic method, serum Cys-C was measured by particle-enhanced immunoturbidimetry. Results The detection rate of abnormal Cys-C in patients with essential hypertension, type 2 diabetes mellitus and metabolic syndrome was significantly higher than that of serum creatinine (52.38%, 39.58%, 58.16%) (16.67%, 25.00%, 45.92% (11.90%, 22.92%, 36.73%). The levels of serum Cys-C in patients with hypertension, diabetes mellitus and metabolic syndrome were significantly higher than those in normal controls (P <0.05) There was no significant difference between BUN and control group (P> 0.05). The level of SCr in metabolic syndrome group was significantly higher than that in control group (P <0.05). Conclusion Serum Cys-C can be used as an auxiliary diagnostic indicator of early renal dysfunction in metabolic syndrome.