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目的 探讨白细胞介素 1(IL 1)对肾小球系膜细胞增殖及周期素依赖激酶 2 (CDK2 )表达的影响。方法 利用体外培养的大鼠肾小球系膜细胞 ,分别采用噻唑蓝掺入法、流式细胞仪检测、免疫细胞化学等方法观察IL 1作用前后系膜细胞增殖情况以及CDK2 的表达变化。结果 IL 1可以明显促进系膜细胞增殖 ,同时伴有CDK2 的表达增高。结论 IL 1对系膜细胞有明显的促增殖作用 ,其机制可能与影响CDK2 的表达有关。
Objective To investigate the effects of interleukin-1 (IL-1) on the proliferation of glomerular mesangial cells and the expression of cyclin-dependent kinase 2 (CDK2). Methods Mesangial cells cultured in vitro were cultured in vitro. The proliferation of mesangial cells and the expression of CDK2 were detected by MTT assay, flow cytometry and immunocytochemistry respectively. Results IL 1 could significantly promote the proliferation of mesangial cells, accompanied by increased expression of CDK2. Conclusion IL 1 has a significant proliferative effect on mesangial cells, and its mechanism may be related to the expression of CDK2.