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目的探讨多西他赛联合奈达铂同步放化疗对中晚期宫颈癌患者生存质量及预后的影响。方法选取2011年3月—2013年10月南阳市中心医院78例Ⅱb~Ⅳa期宫颈癌患者,随机分为对照组和观察组,每组39例。对照组采取盆腔内近距离照射联合盆腔外照射进行放疗,于此基础上观察组予以多西他赛联合奈达铂同步化疗,两组均持续治疗3个月。比较两组治疗前后生存质量(WHOQOL-SF36)评分及临床疗效、不良反应、1年与3年生存率。结果观察组治疗后生存质量评分较对照组提高,差异有统计学意义(P<0.05);经治疗,观察组总有效率87.18%(34/39)高于对照组66.67%(26/39),3年生存率82.05%(32/39)高于对照组61.54%(24/39),差异有统计学意义(P<0.05);两组胃肠道反应、胃功能损害、骨髓抑制等不良反应发生率比较,差异无统计学意义(P>0.05)。结论对中晚期宫颈癌患者应用多西他赛联合奈达铂同步放化疗治疗效果显著,可明显延长患者生存时间,提高其生存质量,且安全性较高。
Objective To investigate the effect of docetaxel combined with nedaplatin on the quality of life and prognosis of patients with advanced cervical cancer. Methods From March 2011 to October 2013, 78 patients with stage IIb-IVa cervical cancer were randomly divided into control group and observation group, 39 cases in each group. The control group received pelvic intraluminal irradiation combined with external pelvic irradiation to perform radiotherapy. On this basis, the observation group received simultaneous chemotherapy with docetaxel and nedaplatin, and both groups continued treatment for 3 months. The quality of life (WHOQOL-SF36) scores before and after treatment in the two groups were compared with clinical efficacy, adverse reactions, and 1-year and 3-year survival rates. Results Compared with the control group, the quality of life score in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the total effective rate in the observation group was 87.18% (34/39) higher than that in the control group (66.67%) (26/39) The 3-year survival rate was 82.05% (32/39) higher than that in the control group (61.54%, 24/39). The difference was statistically significant (P<0.05). The gastrointestinal reactions, gastric function impairment, and bone marrow suppression were not good in the two groups. There was no significant difference in the incidence of the reaction (P>0.05). Conclusions The use of docetaxel combined with nedaplatin in the treatment of cervical cancer patients with advanced chemoradiotherapy has a significant effect, can significantly prolong survival time, improve the quality of life, and high safety.