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目的探讨有氧运动对非酒精性单纯性脂肪肝患者血清超敏C反应蛋白和瘦素的影响。方法选取2009年7-12月在我院健康体检中心诊断为非酒精性单纯性脂肪肝患者100例,均为绝经前女性患者。随机分成基础治疗组和有氧运动组,每组各50例。基础治疗组给予口服维生素C、维生素E、二甲双胍、健康知识宣传教育、改变不良生活方式、低脂饮食等基础治疗。有氧运动组在上述基础治疗同时进行有氧运动。治疗前及治疗后6个月,所有患者检测身高、体重,空腹采取静脉血检测肝功能,超敏C反应蛋白和瘦素水平,检查肝脏B超。结果与基础治疗组比较,干预6月后,有氧运动组患者血清hsCRP和瘦素水平显著降低(P<0.01)。结论有氧运动可显著降低非酒精性单纯性脂肪肝患者血清hsCRP和瘦素水平,可能进一步改善患者转归。
Objective To investigate the effect of aerobic exercise on serum high-sensitivity C-reactive protein and leptin in patients with non-alcoholic simple fatty liver. Methods A total of 100 patients with non-alcoholic simple fatty liver diagnosed in our hospital from July to December 2009 were selected, all of whom were premenopausal women. Randomly divided into basic treatment group and aerobic exercise group, 50 cases in each group. The basic treatment group was given oral vitamin C, vitamin E, metformin, public health education, change the way of life, low-fat diet and other basic treatment. Aerobic exercise group in the above basic treatment of aerobic exercise. Before treatment and 6 months after treatment, all patients were tested for height, weight, fasting blood samples were taken for detection of liver function, high-sensitivity C-reactive protein and leptin levels, liver B ultrasound. Results Compared with the basic treatment group, the levels of hsCRP and leptin in the aerobic exercise group were significantly decreased after 6 months’ intervention (P <0.01). Conclusion Aerobic exercise can significantly reduce serum hsCRP and leptin levels in patients with non-alcoholic simple fatty liver, which may further improve the outcome of patients.