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目前，新型冠状病毒肺炎(COVID-19)疫情已蔓延至全国各地及国外200多个国家和地区。临床一线对COVID-19患者的救治，争议最大的莫过于糖皮质激素的应用。本文旨在从COVID-19的发病机制探讨糖皮质激素应用的时机与方法，以期供临床参考。“,”COVID-19 has spread throughout China and more than 200 countries and regions abroad.The application of glucocorticoids is the most controversial clinical first-line treatment of COVID-19 patients.This paper aims to explore the opportunity and method of the application of glucocorticoids from the pathogenesis of COVID-19, so as to provide clinical reference.