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寨卡病毒(ZIKV)是在过去很长时间曾被忽略、最近又突发的一类人畜共患的蚊传病毒性病原体.该病毒业已席卷西半球的多个国家和地区.2015年,ZIKV在巴西和美国热带地区引起爆发性扩散,同时该病毒感染孕妇后与新生儿的小头畸形症存在罕见的关联性.因此,ZIKV的感染引起世界范围的广泛关注,向公共卫生领域发起了严峻挑战.本研究初步揭示了ZIKV的可能起源和快速扩散机制.系统进化分析显示几乎所有的新发ZIKV都属于亚美系病毒亚类.基于ZIKV E蛋白的结构分析,我们发现其受体结合蛋白具备包括登革热和西尼罗河病毒在内的其他黄病毒类似的结构特征.这提示ZIKV或许已进化出了类似的病毒入侵机制.
Zika virus (ZIKV) is a group of zoonotic pathogens that have been neglected and have recently been abruptly neglected in the past for a number of countries and regions that have swept the Western Hemisphere. In 2015, ZIKV was Brazil and tropical areas of the United States caused an explosive proliferation, while the virus infection in pregnant women and the newborn’s microcephaly rare correlation, therefore, ZIKV infection caused widespread concern around the world, the public health has launched a serious challenge .In this study, the possible origins and rapid diffusion mechanisms of ZIKV were revealed.The phylogenetic analysis showed that almost all new ZIKVs belonged to the subgroups of Amyotrophic America.According to the structural analysis of ZIKV E protein, we found that the receptor binding protein Similar structural features of other flaviviruses, including dengue and West Nile virus, suggest that ZIKV may have evolved a similar mechanism of virus invasion.