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[目的 ]探讨谷胱甘肽S 转移酶M1(GSTM1)和T1(GSTT1)基因多态性与儿童白血病遗传易感性的关系。 [方法 ]采用病例 对照研究方法和多重PCR技术检测病例组和对照组的GSTM1和GSTT1缺失基因型的分布频率。 [结果 ]病例组中GSTM1缺失基因型的分布频率明显高于对照组 (OR =2 .18,95 %CI :1.0 2～ 4.67)。在男性病例中GSTM1缺失基因型的比例高于对照组 (P <0 .0 5 )。GSTM1与GSTT1在儿童白血病的发病中无交互作用。 [结论 ]GSTM1缺失基因型可能是儿童白血病的重要危险因素 ,男性患儿尤为明显 ;GSTT1基因多态性可能与儿童白血病无关 ;GSTM1和GSTT1在儿童白血病的发生过程中可能不存在交互作用
[Objective] To investigate the relationship between glutathione S transferase M1 (GSTM1) and T1 (GSTT1) gene polymorphisms and genetic susceptibility to childhood leukemia. [Methods] Case-control study and multiplex PCR were used to detect the distribution frequency of GSTM1 and GSTT1 deletion genotypes in case group and control group. [Results] The distribution frequency of GSTM1 deletion genotype in case group was significantly higher than that in control group (OR = 2.18, 95% CI: 1.02 ~ 4.67). The proportion of GSTM1-null genotypes in male cases was higher than that in controls (P <0.05). GSTM1 and GSTT1 in the pathogenesis of childhood leukemia no interaction. [Conclusion] The genotype of GSTM1 deletion may be an important risk factor for childhood leukemia, especially in males; GSTT1 gene polymorphism may not be related to childhood leukemia; GSTM1 and GSTT1 may not interact in childhood leukemia