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目的 开展利用MRI增强病灶的定量分析及其对多发性硬化 (MS)治疗前后病情变化的对比研究 ,并观察干扰素 (interferon ,IFN) β1a的疗效。 方法 收集确诊的MS患者 5例 ,治疗前、后各观察 3个月 ,每月做MRI增强造影检查 1次 ,即治疗前后各查MRI 15例次。由专人进行病灶定量处理及治疗前、后对照处理。结果 治疗前、后GD增强病灶阳性例次分别为 10和 7例次 ,总病灶数为 12 1和 38(平均每例次分别为 8 1和2 5)个 (P =0 0 36) ,病灶面积为 34 0 9 4和 142 8 9(平均 2 2 7 3和 95 3)mm2 (P =0 0 69)。结论 MRI定量分析对判定MS病情变化和临床疗效有实用价值 ,IFN β1a对MS患者的近期MRI增强造影病灶的发生有抑制作用
Objective To carry out the quantitative analysis of lesions enhanced by MRI and compare the changes of the disease before and after the treatment of multiple sclerosis (MS) and observe the curative effect of interferon (IFN) β1a. Methods Five patients with confirmed MS were collected. Before and after treatment, they were observed for 3 months. MRI enhanced contrast examination was performed once every month, that is, MRI was performed 15 times before and after treatment. By hand to quantify the lesions and treatment before and after treatment. Results Before and after treatment, the positive cases of GD-enhanced lesions were 10 and 7 cases respectively, the total number of lesions was 12 1 and 38 (the average number of cases were 81 and 25 respectively) (P = 0 36) The area was 34 0 9 4 and 142 8 9 (average 2 2 7 3 and 95 3) mm 2 (P = 0 0 69). Conclusions MRI quantitative analysis is of great value in judging the change of the disease and the clinical curative effect of MS. IFNβ1a can inhibit the recent MRI-enhanced contrast-enhanced lesion in MS patients