To explore a new method for the therapy of the avascular necrosis of the femoral head,the recombinant plasmid pCD-hVEGF165 was mixed with collagen and was implanted in the necroticfemoral head. The expression of vascular endothelial growth factor (VEGF) was detected by RNAdot hybridization and immunohistochemical method. The repair of the femoral head was observed byhistological method. The results showed that the expression of VEGF was detectable in the femoralhead treated with VEGF gene. Angiogenesis in these femoral heads was more abundant than thecontrol. Bone repairing was augmented in the femoral head treated with VEGF gene. The resultssuggest that angiogenesis in bone tissue could be augmented by gene transfection of VEGF and bonerepairing would be accelerated accordingly.