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T细胞在胸腺内的分化过程目前还不完全清楚。对小鼠胚胎发育不同阶段的胸腺细胞进行表型分析有利于揭示胸腺细胞的分化过程。已有资料表明,Lyt-2~-和L_3T_4~-双阴性胸腺细胞(DN 细胞)是T 细胞的前体细胞;Pgp-1抗原是最早期胸腺细胞的表面标志之一;过继转移实验表明,J11d~+DN胸腺细胞具有再定居胸腺的能力,而J11d~-DN 胸腺细胞则否。本文应用Thy-1、J11d、Pgp-1、IL-2R、Lyt-2及L_3T_4的单克隆抗体采用双荧光染色流式细胞术分析了鼠早期胚胎不同发育阶段胸腺细胞上相应膜分子表达的动态变化及其相互关系。结果表明:
T cell differentiation in the thymus is not yet fully understood. Phenotypic analysis of thymocytes in different stages of mouse embryo development is helpful to reveal the process of thymocyte differentiation. It has been reported that Lyt-2 ~ - and L_3T_4 ~ - double negative thymocytes (DN cells) are precursor cells of T cells; Pgp-1 antigen is one of the surface markers of the earliest thymocytes; Adoptive transfer experiments show that, J11d ~ + DN thymocytes have the ability to re-colonize the thymus, while J11d ~ -DN thymocytes are not. In this study, we analyzed the expression of corresponding membrane molecules on thymocytes in different developmental stages of mouse embryos by double-fluorescence staining using monoclonal antibodies against Thy-1, J11d, Pgp-1, IL-2R, Lyt-2 and L_3T_4 Changes and their relationships. The results show: