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目的:研究“化瘀方”对内毒素(LPS)诱导脓毒症大鼠心肌损伤的保护作用。方法:采用“化瘀方”(丹参、大黄)高、中、低剂量预处理7 d,LPS注射诱导脓毒症后取材,分析大鼠血常规、血清心肌酶谱和心肌细胞超微结构的变化。结果:“化瘀方”各剂量组大鼠血清CK、CK-MB水平较模型组明显降低,并且心肌细胞损伤程度明显轻于模型组;“化瘀方”可明显降低血液中白细胞和中性粒细胞的数目。结论:“化瘀方”预处理可以明显抑制脓毒症大鼠心肌损伤,作用机制可能为抑制炎症反应。
Objective: To study the protective effect of “Huayu Recipe” on myocardial injury induced by endotoxin (LPS) in septic rats. Methods: High, medium and low doses of “Hua Yu Fang” (Salviae Miltiorrhizae, Rhubarb) were pretreated for 7 days. After sepsis induced by LPS injection, blood samples were collected and the myocardial enzymes and ultrastructures Structural changes. Results: The levels of CK and CK-MB in serum of rats in each group were significantly lower than those in model group, and the degree of cardiomyocyte injury was significantly lower than that in model group. “Huayu Recipe” The number of white blood cells and neutrophils. Conclusion: Pretreatment with “Huayu Recipe” can significantly inhibit myocardial injury in septic rats, and its mechanism may be to inhibit the inflammatory reaction.