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目的 :观察丹参注射液对脑梗塞急性期血浆中一氧化氮 (NO)、内皮素 (ET)的影响。方法 :将 72例急性脑梗塞患者随机分为治疗组和对照组进行血浆 NO、ET的动态观察。结果 :在发病 72小时内 ,脑梗塞组血浆 ET明显升高 ,NO明显下降 ,与正常组比较 P均 <0 .0 1 ;治疗后两组 ET均有明显下降 (P<0 .0 1 ) ,NO有明显升高 (P<0 .0 1 ) ,但治疗组 ET降低 ,NO升高均较对照组显著(P<0 .0 5)。结论 :脑梗塞急性期应用活血化瘀中药有助于改善梗塞灶局部的血液供应 ,有助于抢救梗塞灶的半暗带
Objective: To observe the effect of Danshen injection on plasma levels of nitric oxide (NO) and endothelin (ET) in the acute stage of cerebral infarction. Methods: Seventy-two patients with acute cerebral infarction were randomly divided into treatment group and control group for dynamic observation of plasma NO and ET. Results: Within 72 hours after onset, the plasma ET increased significantly and the NO decreased significantly compared with the normal group (P <0.01); ET decreased significantly after treatment (P <0.01) , NO increased significantly (P <0.01), but ET decreased and NO increased significantly in the treatment group compared with the control group (P <0.05). Conclusion: The application of traditional Chinese medicine in the acute phase of cerebral infarction helps to improve the local blood supply of infarction and helps to rescue the penumbra of infarction