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目的探讨阿德福韦酯联合肝宁片治疗甲胎蛋白(AFP)升高的慢性乙型肝炎(CHB)的疗效。方法 AFP升高的CHB患者58例,分成治疗组29例和对照组29例。治疗组给予阿德福韦酯(10mg/d)联合肝宁片(每天3次,每次3片)治疗;对照组单用阿德福韦酯(10mg/d)治疗。治疗12、24和48周检测ALT、AFP和HBV DNA等指标,随访3年,观察疗效。结果治疗12、24和48周,治疗组ALT复常率和AFP复常率较对照组高(P<0.05或P<0.01),两组HBV DNA转阴率比较无统计学差异(P>0.05)。随访3年,治疗组无肝癌发生,对照组3例发生肝癌。结论阿德福韦酯联合肝宁片治疗AFP升高的CHB患者能抑制肝细胞过度增生,促进肝脏炎症恢复。
Objective To investigate the curative effect of adefovir dipivoxil combined with huang ning tablet on chronic hepatitis B (CHB) with elevated AFP. Methods Fifty-eight CHB patients with elevated AFP were divided into treatment group (n = 29) and control group (n = 29). The treatment group was given adefovir dipivoxil (10mg / d) combined with liver Ning tablets (3 tablets three times a day); the control group was treated with adefovir dipivoxil alone (10mg / d). ALT, AFP and HBV DNA were detected at 12, 24 and 48 weeks after treatment, and were followed up for 3 years to observe the curative effect. Results After treatment for 12, 24 and 48 weeks, the ALT recovery rate and AFP recovery rate in the treatment group were significantly higher than those in the control group (P <0.05 or P <0.01). There was no significant difference in HBV DNA conversion rate between the two groups (P> 0.05 ). Follow-up 3 years, the treatment group without liver cancer, control group, 3 cases of liver cancer. Conclusions Adefovir dipivoxil combined with Gan Ning tablets in the treatment of CHB patients with elevated AFP can inhibit hepatocyte hyperplasia and promote the recovery of liver inflammation.