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本文报道135例狼疮性肾炎长期观察(1962～1984)的结果,旨在强调肾活检和尿分析作为疾病活动性和进展的一项指标,在指导治疗方面具有重大意义.135例肾活检按改良的WHO标准进行分类:轻度肾小球膜损害17%,灶性损害10%,轻度弥漫性增殖性损害21%,严重弥漫性增殖性损害37%,膜性损害15%.灶性组织和弥漫性增殖性组(213次活检)采用半定量记分.全部患者5年和10年的生存率分别为83%和65%,严重弥漫性增殖组和其他增殖性组相比,有明显的不良结果(P<0.01),仅这组患者发展为终末期肾功能衰竭.死亡者共23例,5例死于肾功能衰
This article reports the results of 135 long-term observations of lupus nephritis (1962-1984) aimed at emphasizing renal biopsy and urinalysis as an indicator of disease activity and progression, which are of great importance in guiding treatment.135 cases of renal biopsy by modified Of the WHO criteria for classification: mild glomerular membrane damage 17%, focal lesion 10%, mild diffuse proliferative damage 21%, severe diffuse proliferative damage 37%, membranous damage 15% .Focal tissue And diffuse proliferative group (213 biopsies) were scored semi-quantitatively.The survival rates at 5 years and 10 years of all patients were 83% and 65%, respectively.Compared with other proliferative groups, Adverse outcomes (P <0.01), only this group of patients developed end-stage renal failure, a total of 23 deaths, 5 patients died of renal failure