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目的建立妊娠各期的甲状腺激素参考值。方法选取天津市不同区县的常住孕产妇,孕早期132例,孕中期120例,孕晚期125例,采用化学发光免疫分析法检测促甲状腺激素(TSH)、游离甲状腺激素(FT_4)。结果天津地区妊娠期甲状腺激素参考值为:孕早期TSH(0.06~4.11)m IU/L,FT_4(12.08~20.07)pmol/L;孕中期TSH(0.05~3.35)m IU/L,FT_4(10.98~17.34)pmol/L;孕晚期TSH(0.50~3.38)m IU/L,FT_4(10.10~16.39)pmol/L。结论妊娠不同时期的TSH、FT_4水平略有波动,参考值范围与《妊娠与产后甲状腺疾病诊治指南》略有差异,说明建立天津市妊娠期甲状腺激素参考值具有临床指导意义和应用价值。
Objective To establish thyroid hormone reference value during pregnancy. Methods Totally 132 pregnant women, 120 pregnant women, 125 pregnant women and 125 pregnant women were enrolled in this study. Totally thyroid stimulating hormone (TSH) and free thyroid hormone (FT_4) were detected by chemiluminescence immunoassay. Results The reference values of gestational thyroid hormone in Tianjin during the first trimester were TSH (0.06-4.11) mIU / L and FT 4 (12.08-20.07) pmol / L in the first trimester, TSH (0.05-3.35) mIU / L and FT 4 (10.98 ~ 17.34) pmol / L; third trimester TSH (0.50 ~ 3.38) m IU / L, FT_4 (10.10 ~ 16.39) pmol / L. Conclusions The levels of TSH and FT_4 in different stages of pregnancy fluctuate slightly. The range of reference values is slightly different from the guidelines for the diagnosis and treatment of thyroid diseases in pregnancy and postpartum. It is of clinical significance and value to establish the reference value of thyroid hormone in pregnancy in Tianjin.