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人类Y染色体的多态性变异已为人们熟知,但对其变异的生物学及临床意义,至今认识不一。一些学者认为,Y染色体长臂增长与身高、行为异常及妻子流产等有关,而另一些人则认为这种变异无任何临床意义。在以往的研究中,由于测量Y染色体长度的方法及标准不同,相互间很难比较。本文通过对152例正常汉族男性Y染色体相对长度(Y/F值)的测量分析,探讨我国汉族男性Y/F平均值和大Y的标准,并对其变异与某些表型之间的关系进行探讨。 材料与方法 1.对象:20～50岁汉族男性献血者。大部分为北京地区工人、农民,小部分为空军干部,战士。未婚68例,已婚84例。经全面体检,无特殊疾病。本人及家族中无遗传病史,已育的73例中,其妻均无流产史。
Human Y chromosome polymorphism variation is well known, but the biological and clinical significance of its variation, so far divergent understandings. Some scholars believe that long arm growth of the Y chromosome is associated with height, abnormal behavior and miscarriage of wives, while others believe the mutation has no clinical significance. In previous studies, it was difficult to compare with each other due to different methods and standards for measuring the length of the Y chromosome. In this paper, 152 normal Han male Y chromosome relative length (Y / F value) measurement analysis of Chinese Han men Y / F average and large Y standards, and its variation and the relationship between some phenotype To explore. Materials and methods 1 object: 20 to 50-year-old Han male blood donor. Most of them are workers and peasants in Beijing and a small part are air force cadres and fighters. 68 cases of unmarried, 84 cases of married. After a comprehensive medical examination, no special disease. I and family without genetic history, 73 cases have been educated, his wife had no history of abortion.