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目的:探讨磁共振成像脑小血管病(cerebral small vessel disease, CSVD)总体负担与急性缺血性卒中患者卒中后抑郁(post-stroke depression, PSD)的相关性。方法:回顾性纳入2017年1月至2018年9月期间济南市人民医院神经内科收治的急性缺血性卒中患者。入院后完善头颅MRI检查，根据CSVD总体负担评分量表进行评分。在发病后3个月时评价PSD。比较PSD组与非PSD组人口统计学、临床资料及磁共振成像CSVD总体负担。应用多变量n logistic回归分析确定CSVD总体负担与PSD的相关性。n 结果:共纳入102例急性缺血性卒中患者，年龄(65.86±11.41)岁，男性56例(54.9%)，基线NIHSS评分(5.08±2.55)分。19例(18.6%)CSVD总体负担为重度，42例(41.2%)发生PSD。单变量分析显示，PSD组基线舒张压以及高血压、卒中分布、梗死侧别、腔隙性梗死、基底节区血管周围间隙扩大、基底节区脑微出血、脑室周围白质高信号、深部白质高信号和CSVD总体负担重的患者比例与非PSD组差异有统计学意义(n P均<0.05)。多变量n logistic回归分析显示，CSVD总体负担[优势比(odds ratio, n OR)4.68，95%可信区间(confidence interval, n CI)1.19～18.49；n P＝0.028]、基底节区血管周围间隙扩大(n OR 4.61，95% n CI 1.49～14.20；n P＝0.008)、高血压(n OR 4.82，95% n CI 1.40～16.64；n P＝0.013)和脑室周围白质高信号(n OR 2.18，95% n CI 1.01～4.67；n P＝0.046)与PSD显著独立相关。n 结论:CSVD总体负担与缺血性卒中患者PSD密切相关。“,”Objective:To investigate the correlation between the overall burden of cerebral small vessel disease (CSVD) and post-stroke depression (PSD) in patients with acute ischemic stroke.Methods:Patients with acute ischemic stroke admitted to the Department of Neurology, Jinan People's Hospital from January 2017 to September 2018 were enrolled retrospectively. After admission, the head MRI was performed and scored according to the CSVD overall burden score scale. The PSD was evaluated at 3 months after onset. They were divided into PSD group and non-PSD group. The demographic, clinical data and overall burden of CSVD were compared between the two groups. Multivariaten logistic regression analysis was used to identify the correlation between the overall burden of CSVD and PSD.n Results:A total of 102 patients with acute ischemic stroke were enrolled, aged 65.86±11.41 years old, and 56 were males (54.9%). The baseline NIHSS score was 5.08±2.55. The overall burden of CSVD in 19 patients (18.6%) was severe, and 42 (41.2%) had PSD. Univariate analysis showed that there were significantly different differences in baseline diastolic blood pressure and the proportion of patients with hypertension, stroke distribution, infarcted side, lacunar infarction, enlarged perivascular space in the basal ganglia, cerebral microbleedings in basal ganglia, periventricular white matter hyperintensities, deep white matter hyperintensities and severe overall burden of CSVD between the PSD group and the non-PSD group (all n P<0.05). Multivariaten logistic regression analysis showed that severe overall burden of CSVD (odd ratio [n OR] 4.68, 95% confidence interval [n CI] 1.19-18.49; n P=0.028), enlarged perivascular space in basal ganglia (n OR 4.61, 95% n CI 1.49-14.20; n P=0.008), hypertension (n OR 4.82, 95% n CI 1.40-16.64; n P=0.013) and periventricular white matter hyperintensities (n OR 2.18, 95% n CI 1.01-4.67; n P=0.046) were significantly independently correlated with PSD.n Conclusion:The overall burden of CSVD was closely associated with PSD in patients with ischemic stroke.