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目的探讨非小细胞肺癌患者外周血循环肿瘤细胞(CTCs)检测的临床意义。方法采用CellSearch系统检测30例非小细胞肺癌患者外周血中循环肿瘤细胞数,并与15例肺良性疾病患者、30例健康志愿者(对照组)进行比较。结果CTCs>0的非小细胞肺癌患者为20例(66.7%),肺良性疾病患者为4例(26%),健康志愿者为0例;CTCs>5的分别为:9(30%)、0、0例;CTCs>10的分别为:4(13%)、0、0例,均有统计学差异(P<0.05)。不同临床分期患者比较,Ⅰ、Ⅱ期患者外周血中的CTCs的阳性百分率(29.6%)显著低于Ⅲ、Ⅳ期患者(58.3%),差异有统计学意义(P<0.05)。结论采用CellSearch系统,可以早期检测非小细胞肺癌患者外周血CTCs,有望成为一种实用的循环肿瘤细胞检测技术。
Objective To investigate the clinical significance of detection of circulating tumor cells (CTCs) in patients with non-small cell lung cancer. Methods CellSearch system was used to detect circulating tumor cells in peripheral blood of 30 patients with non-small cell lung cancer and compared with 15 patients with benign lung disease and 30 healthy volunteers (control group). RESULTS: Twenty patients (66.7%) had non-small-cell lung cancer with CTCs> 0, 4 patients (26%) with benign lung disease, and 0 patients with healthy volunteers; 9 (30%) with CTCs> 0,0 cases; CTCs> 10 were: 4 (13%), 0,0 cases, were statistically significant (P <0.05). The positive percentage of CTCs in peripheral blood of patients with stage Ⅰ and Ⅱ (29.6%) was significantly lower than that of patients with stage Ⅲ and Ⅳ (58.3%) in different clinical stages (P <0.05). Conclusion The use of CellSearch system can detect CTCs in peripheral blood of patients with non-small cell lung cancer early and may become a practical detection technology of circulating tumor cells.