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应用小扁豆凝集素(LCA)亲和交叉免疫电泳自显影法测定了肝癌病人血情及癌组织中的甲胎蛋白异质体(AFP异质体)并与肝硬变和非肝癌病人做对照。结果表明,应用LCA分离的AFP异质体只有两种,不同地区的肝癌病人其AFP异质体类型不尽一致,癌组织中的AFP异质体其百分含量与血清中接近,提示肝内存在着分泌两种异质体的肝癌细胞,AFP-N-L百分含量变化与肿瘤大小、癌细胞分化程度、组织学类型,肿瘤包膜、癌栓等因素有关、肿瘤恶性程度高者以分泌LCA结合型AFP为主。
Affinity cross-immunoelectrophoresis autoradiography using lentil lectin (LCA) was used to determine the alpha-fetoprotein heteroplasmy (AFP heterogeneity) in patients with hepatocellular carcinoma and compared with cirrhotic and non-hepatocellular carcinoma patients. . The results showed that there were only two AFP heterologous organisms isolated by LCA. Hepatoma patients in different regions had different AFP heterogeneity types. The percentage of AFP heterogeneity in cancer tissues was similar to that in serum, indicating that the liver was in memory. In hepatoma cells that secrete two types of foreign bodies, the percentage of AFP-NL changes with tumor size, differentiation of cancer cells, histological type, tumor capsule, and tumor thrombus, among others, and those with higher tumor malignancy to secrete LCA. The main type is AFP.