maspin是最初从正常乳腺上皮细胞中分离出的一个候选肿瘤抑制基因,编码产物属丝氨酸蛋白酶抑制剂超家族,卵清蛋白亚族。体外细胞培养及动物实验研究表明,maspin具有抑制肿瘤细胞运动、侵袭、转移、抗血管新生和诱导凋亡等作用。目前对maspin抗瘤机制的研究方兴未艾,但其与妇科肿瘤的关系报道不多。综述mapin的结构、功能及其对细胞凋亡、血管新生、细胞黏附、表遗传学调节过程的影响以及在妇科肿瘤发病过程中的作用。 Maspin, a candidate tumor suppressor originally isolated from normal mammary epithelial cells, encodes the serine protease inhibitor superfamily, the ovalbumin subfamily. In vitro cell culture and animal experiments show that maspin can inhibit tumor cell motility, invasion, metastasis, anti-angiogenesis and induce apoptosis. Currently on the maspin anti-tumor mechanism in the ascendant, but its relationship with gynecologic oncology reported little. This review summarizes the structure and function of mapin and their roles in the regulation of apoptosis, angiogenesis, cell adhesion and epigenetic regulation and the role of mapin in the pathogenesis of gynecologic oncology.