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人肝癌细胞株BEL—7402对长春碱类抗癌药物长春新碱(VCR)和长春酰胺(VDS)表现出天然抗药性。钙通道阻滞剂凡拉帕米(戊脉安,Verapamil,VP)和加洛帕米(甲氧戊脉安,Gallopamil,GP)在本身不引起细胞毒作用的浓度下,能显著地增加VCR和VDS对BEL—7402细胞株的细胞毒性。VP和GP对VCR和VDS的增效作用随其剂量的增加及联合用药时间的延长而加强,但各联合用药组之间的增效程度没有差异。 VP和GP在本身无体内抑瘤活性的剂量下与VCR联用,能显著地增强VCR对实体型艾氏腹水癌的抑瘤作用。
The human hepatoma cell line BEL-7402 showed natural resistance to the Vinca alkaloids vincristine (VCR) and vinacamide (VDS). The calcium channel blockers verapamil (Verapamil, VP) and gallopamil (Gallopamil, GP) can significantly increase VCR at concentrations that do not cause cytotoxicity by themselves. The cytotoxicity of VDS on BEL-7402 cell line. The synergistic effects of VP and GP on VCR and VDS increased with increasing dose and duration of combination, but there was no difference in the degree of synergy between the groups. VP and GP are combined with VCR at a dose that does not have in vivo anti-tumor activity, and can significantly enhance the anti-tumor effect of VCR on solid Ehrlich ascites carcinoma.