以己二酸和无水甲醇为原料,一水合硫酸氢钠为催化剂合成了己二酸二甲酯,考察了醇酸摩尔比、催化剂用量、反应时间对酯化反应的影响,确定了合成己二酸二甲酯的最佳反应条件：n(己二酸)：n(无水甲醇)：n(一水合硫酸氢钠)=1：5：0．29,回流分水60 min,己二酸二甲酯收率达97．48％,纯度在98％以上。实验结果表明,一水合硫酸氢钠对合成己二酸二甲酯具有良好的催化活性。 Adipic acid and anhydrous methanol as raw materials, sodium bisulfate monohydrate as catalyst synthesis of dimethyl adipate, investigated the molar ratio of alkyd, the amount of catalyst, the reaction time on the esterification reaction, confirmed the synthesis of The best reaction conditions of dimethyl dodecyl alcohol: n (adipic acid): n (anhydrous methanol): n (sodium bisulfate monohydrate) = 1: 5: 0.29, Acid dimethyl ester yield of 97.48%, the purity of more than 98%. The experimental results show that sodium bisulfite monohydrate has good catalytic activity for the synthesis of dimethyl adipate.