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为比较流行性乙型脑炎 (乙脑 )减毒活疫苗和灭活疫苗的免疫效果和安全性 ,选择北京市 1～ 2周岁应初免儿童 2 6 4名 ,分组接种乙脑减毒活疫苗和乙脑灭活疫苗 ,观察人体接种反应 ,采用细胞蚀斑减少中和试验检测免疫前及免疫后血清乙脑中和抗体。结果显示 :减毒活疫苗组抗体阳转率和阳性抗体几何平均滴度 (GMT)分别为91 30 %和 1∶2 0 2 2 ;灭活疫苗组为 6 4 38%和 1∶16 5 1。经统计学分析 ,减毒活疫苗组抗体阳转率和阳性抗体GMT均高于灭活疫苗组。经观察 ,减毒活疫苗组和灭活疫苗组人体反应均为发热和接种部位轻度红肿 ,发热率分别为 8 5 1%和 8 13% ,中、强反应率为 2 13%和 0 81% ,红肿率为 1 4 2 %和 0 81%。所有发热及轻度红肿者均于2 4h恢复正常。提示 :乙脑减毒活疫苗免疫效果好 ,免疫针次少 ,安全性好 ,是现阶段预防乙脑比较理想的疫苗 ,适宜推广使用
In order to compare the immunogenicity and safety of attenuated live attenuated JE vaccine and inactivated vaccine, 2 4 4 children should be initially immunized in Beijing from 1 to 2 years old. Vaccine and JE inactivated vaccine, observation of human inoculation reaction, using cell plaque reduction and neutralization test before and after immunization of serum JE neutralizing antibodies. The results showed that the GMT of live attenuated vaccine group was 91 30% and 1 022 2, respectively, and the inactivated vaccine group was 64 48% and 1:16 5 1 . After statistical analysis, live attenuated vaccine group positive rate of antibody positive and GMT were higher than inactivated vaccine group. It was observed that the live attenuated vaccine group and the inactivated vaccine group were both mild fever and inoculation site mild fever, fever rates were 851% and 81.3%, moderate and strong response rates were 21.3% and 0 81 %, Redness rate was 14.2% and 0 81%. All fever and mild redness were returned to normal within 2 4h. Tip: JE attenuated live vaccine immunization effect is good, less immunization needles, good safety, is the current stage of prevention of JE ideal vaccine, suitable for promotion use