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肾细胞癌是泌尿系统常见恶性肿瘤之一。目前对于转移性肾癌的主要治疗方式是分子靶向治疗,该方法利用肾癌组织与正常组织在某些基因、信号转导途径等分子生物学上的差异,通过靶向药物作用于特定的靶点、信号通路来抑制肿瘤细胞生长增殖,进而发挥抗肿瘤作用。本文就目前国内外临床上主要的靶向药物治疗转移性肾癌的现状和进展进行综述。
Renal cell carcinoma is one of the common malignant tumors of the urinary system. At present, the main treatment for metastatic renal cell carcinoma is molecular targeted therapy, which utilizes the molecular biological differences among certain genes and signal transduction pathways in renal cell carcinoma and normal tissues, and targets the drugs to specific Target, signal pathway to inhibit tumor cell growth and proliferation, and then play an antitumor effect. This review summarizes the current status and progress of the main targeted drugs in the treatment of metastatic renal cell carcinoma at home and abroad.